Objective: To establish an HPLC method for the simultaneously determination of chlorogenic acid,caffeic acid and mangiferin in Shiwei Dispensing Granule. Method: Chlorogenic acid,caffeic acid and mangiferin were separated on Shim-pack VP-ODS (4.6 mm×250 mm,5 μm) column and detected at 323 nm (0~30 min) and 258 nm (30.1~45 min),with acetonitrile-0.1% phosphoric acid solution (9 ∶91) as mobile phase. The flow rate was 1.0 mL ·min^-1. Result: Chlorogenic acid,caffeic acid and mangiferin were linear within the range of 129.6~302.4 mg ·L^-1 ( r =0.999 8),13.8~32.2 mg ·L^-1 ( r =0.999 9) and 151.2~352.8 mg ·L^-1 ( r =0.999 9) respectively. The average recovery were 98.15% (RSD 1.69%),99.93% (RSD 2.98%) and 101.43% (RSD 2.00%). Conclusion: The method is simple,reproducible,and it can be used for the quality control of Shiwei Dispensing Granule.