Objective: To investigate the influence of extracts of Paederia scandens (EPS) on blood glucose and anti-oxidative effect in streptozotocin(STZ)-induced diabetic mice. Method: Diabetic mice were established by vein intravenous injection with STZ (120 mg·kg^-1). The diabetic mice were randomly divided into five groups, each group was consist of 10 mice:model group, metformin group, low-, medium-, high-dose (2.5, 5, 10 g·kg^-1) of EPS groups. Another 10 normal mice were considered as normal control group. The mice were administrated with drugs for 14 days, and the fasted blood glucose (FBG) was determined at 0^th day, 7^th day and 14^th day. After 14 days, the superoxide dismutase(SOD), malondialdehyde(MDA) and glutathione peroxidase(GSH-Px) activities in serum and liver tissue were measured. Result: Compared to normal control group, the serum and liver tissue levels of SOD and GSH-Px in model group were significantly decreased, and the FBG and MDA levels were increased. The FBG of EPS administration groups were significantly decreased compared with model group. While the serum and liver tissue levels of SOD and GSH-Px were elevated and the MDA content was decreased after EPS administration. Conclusion: The hypoglycemic mechanism of EPS on diabetic mice was likely involved in improving the anti-oxidative capability of liver tissue.