At present, the research on anti-tumor activity of the total saponins of Aralia eleta has made certain progress, which mainly related to transplantation tumor model of human lung adenocarcinoma, breast cancer, mouse ascites tumor in vitro and cell studies on human hepatocellular carcinoma, human colon cancer, gastric cancer, ovarian cancer and human erythroleukemia in vivo. In order to understand the research status of total saponin of Aralia eleta in anti-tumor activity, and investigate the anti-tumor effect, we compared our research to the previous research on cell concentration, the dose and the usage time of total saponins in tumor model in vitro and in vivo. Finally, we discovered that the total saponins were effective at a dosage of 50 mg·kg^-1 in vitro, and the different dose interval and duration have different effect. However, the different dose has different effect in vivo too. These researches provide the experimental basis for clinic application and pharmacological action for total saponins of Aralia eleta.