Objective: To compare effect of different extraction technology (water extraction of whole prescription, water extract-alcohol precipitation of Gardeniae Fructus and alcohol extraction of Oroxyli Semen and Sophorae Flavescentis Radix, alcohol extraction of whole prescription, they were referred to as process 1, 2 and 3) on anti-inflammatory, analgesic and antipyretic action of Feiduqing. Method: Anti-inflammatory effect of Feiduqing with different extraction technology was compared by inflammation test induced by xylene in mice;through glacial acetic acid writhing test to compare analgesic effect of Feiduqing with different extraction technology;by 2, 4-dinitrophenol induced rat fever to compare antipyretic effect of Feiduqing with different extraction technology. Result: Sample of process 1 could significantly inhibit inflammation induced by xylene in mice and sample of process 2 could significantly inhibit inflammation induced by xylene in mice.Sample of process 1 could significantly inhibit times of writhing caused by acetic acid;samples of process 2 and 3 could significantly inhibit times of writhing caused by acetic acid;inhibition rate of sample of process 2 was higher than sample of process 3.Sample of process 2 could significantly inhibit fever induced by 2, 4-dinitrophenol. Conclusion: Extraction process has great impact on efficacy of Feiduqing;anti-inflammatory, analgesic and antipyretic effect of sample of process 2 is the best.