Objective: To explore the influence of the cold or heat prescription on ulcer with cold or heat syndrome in gastric ulcer model rats induced by pylorus deligation or smearing acetic.Then to verify the feasibility of this model from the point of pharmacodynamics,and to elucidate the objective regularity of 'formula-syndrome corresponding’. Method :Adopting cold or heat factors combined with pylorus deligation or smearing acetic acid methods,gastric ulcer model combined with cold and heat syndrome was established.Then the ulcer indexes were observed. Result: The ulcer indexes of'disease-syndrome combination model group’ are all higher than the 'simple disease model group’ obviously,and the differences are significant(P<0.01).Compared to the 'disease-syndrome combination model groups’,the ulcer indexes decreased in Dahuang Huanglian Xiexin Decoction therapeutic group or Lizhong Pill therapeutic group remarkably(P<0.05 or P<0.01).The therapeutic action of cold prescription Dahuang Huanglian Xiexin Decoction on heat model is superior to heat prescription Lizhong Pill.The therapeutic action of heat prescription Lizhong Pill on cold model is superior to cold prescription Dahuang Huanglian Xiexin Decoction,(P<0.05). Conclusion: Dahuang Huanglian Xiexin Decoction has conspicuous preventive and therapeutic effects.Lizhong Pill performs remarkable preventive and therapeutic effects.They both can decrease the ulcer indexes for corresponding model,indicating certain objective regularityof 'formula-syndrome corresponding’.