| 赵美华,荣烨之,吕宝经,朱向阳,黄国芳,杨谨文.生脉散对急性病毒性心肌炎患者血清脂质过氧化物的影响[J].中国中西医结合杂志,1996,(3):142-145 |
| 生脉散对急性病毒性心肌炎患者血清脂质过氧化物的影响 |
| Effect of Shengmaisan on Serum Lipid Peroxidation in Acute Viral Myocarditis |
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| DOI： |
| 中文关键词: 病毒性心肌炎 生脉散 抗脂质过氧化物 |
| 英文关键词:viral myocarditis Shenginaisan anti-lipid peroxidation |
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| 摘要点击次数: 1248 |
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| 中文摘要: |
| 本研究观察了生脉散对急性病毒性心肌炎患者血中超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）、丙二醛（ＭＤＡ）等指标的影响。结果发现病毒性心肌炎患者中ＳＯＤ、ＧＳＨ－Ｐｘ明显低于健康人（Ｐ＜０．００１），ＭＤＡ明显高于健康人（Ｐ＜０．００１）。６２例病毒性心肌炎患者分生脉散组和对照组，结果发现生脉散组（３５例）患者血中ＳＯＤ、ＧＳＨ－Ｐｘ较服药前明显增加（Ｐ＜０．００１）；ＭＤＡ显著降低（Ｐ＜０．００１）。对照组（２７例）服药前、后ＳＯＤ、ＧＳＨ－Ｐｘ及ＭＤＡ无明显改变（Ｐ＞０．０５）。提示病毒性心肌炎患者心肌损伤与脂质过氧化反应有密切关系。生脉散具有抗氧自由基和抗脂质过氧化作用。能防治心肌损伤，是对病毒性心肌炎的有效治疗措施之一。 |
| 英文摘要: |
| The effect of Shengmaisan(SMS) on 62 acute viral myocarditis patients and its peroxidation damage was studied. The results revealed that the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) in blood were decreased and the content of malondialdehyde(MDA) in plasma was increased in acute viral myocarditis patients in comparison with the healthy controls(P<0.001). 62 acute viral myocarditis patients were divided into two groups: SMS group and placebo group. After treatment, both SOD and GSH-Px activities were increased and the level of MDA decreased (P<0.001) in SMS group, while those in placebo group were not changed(P<0.05). The results suggested that the myocardial damage of viral myocarditis is closely related with lipid peroxidation SMS acts as an effective free radical scavenger and anti-lipid peroxidation drug. SMS could prevent the damage of myocardia and might be taken as one of the effective therapeutic methods in treatment of acute viral myocarditis. |
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