丹莪合剂治疗子宫内膜异位症的临床及实验研究

作者	单位
蔡利珊	Cai Lishan, Shu Ye, Xie Huiying, et al The Second Affiliated Hospital, Kunming Medical College, Yunnan (650101
舒晔	Cai Lishan, Shu Ye, Xie Huiying, et al The Second Affiliated Hospital, Kunming Medical College, Yunnan (650101
谢辉英	Cai Lishan, Shu Ye, Xie Huiying, et al The Second Affiliated Hospital, Kunming Medical College, Yunnan (650101
孙琰	Cai Lishan, Shu Ye, Xie Huiying, et al The Second Affiliated Hospital, Kunming Medical College, Yunnan (650101
王文会	Cai Lishan, Shu Ye, Xie Huiying, et al The Second Affiliated Hospital, Kunming Medical College, Yunnan (650101
毛先珍	Cai Lishan, Shu Ye, Xie Huiying, et al The Second Affiliated Hospital, Kunming Medical College, Yunnan (650101
杜玲	Cai Lishan, Shu Ye, Xie Huiying, et al The Second Affiliated Hospital, Kunming Medical College, Yunnan (650101
章小琴	Cai Lishan, Shu Ye, Xie Huiying, et al The Second Affiliated Hospital, Kunming Medical College, Yunnan (650101
阎兆珍	Cai Lishan, Shu Ye, Xie Huiying, et al The Second Affiliated Hospital, Kunming Medical College, Yunnan (650101
傅彩娥	Cai Lishan, Shu Ye, Xie Huiying, et al The Second Affiliated Hospital, Kunming Medical College, Yunnan (650101

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中文摘要:

目的：寻找治疗子宫内膜异位症（内异症）既有效、副作用又少的药物。方法：应用纯中药制剂———丹莪合剂治疗内异症１８９例，观察治疗前后一些指标的变化，并且还观察了实验动物模型用丹莪合剂及丹那唑治疗后的情况。结果：内异症患者１８９例经丹莪合剂治疗９个月，临床痊愈３９例占２０６％；显效６７例占３５４％；有效６７例占３５４％；无效１６例占８５％，总有效率为９１５％。与丹那唑同疗程治疗内异症患者１６０例的总有效率９５０％比较，无显著性差异。动物实验结果也与临床相似。结论：丹莪合剂是治疗内异症的一种安全、有效的药物，值得进一步研究及开发，特别对该病的早期诊断、早期治疗及预防独具特色。

英文摘要:

Objective: To find a medicine to treat endometriosis effectively with less side effect. Methods: Dan’e mixture (DEM, consists of Radix Salviae Miltiorrhizae and Rhizoma Zedoariae) was used to treat 189 cases of endometriosis and the change of symptom and sign, the B ultrasonograph, the anti endometrium antibody and endometriosis quantitative diagnostic index were observed, another 160 cases were treated with Danazol as control, also using animal model to treat with DEM and Danazol. Results: One hundred and eighty nine cases were treated for 9 months. According to National Standards, 39 cases (20.6%) were cured, 67 cases (35.4%) were markedly effective, 67 cases (35.4%) were effective, and 16 cases (8.4%) were ineffective. Compared with 160 cases treated with Danazol for 9 months, the total effective rates were 95% and 91.5% respectively, the difference between them was insignificant. Animal experiments showed the similar results to the clinical ones. Conclusion: SZM is a safe and effective medicine to treat endometriosis, which deserves further study and development. It is particularly helpful for diagnosis, treatment and prevention of endometriosis in the early stage.

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