健脾疏肝除湿化瘀法对腹泻型肠易激综合征患者近期生活质量影响的研究

Effect of TCM Therapy for Invigorating Pi,Soothing Gan,Eliminating Dampness and Resolving Blood Stasis on the Short-term Quality of Life in Patients with Diarrhea Type Irritable Bowel Syndrome

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中文关键词: 健脾疏肝除湿化瘀腹泻型肠易激综合征生活质量

英文关键词:invigorating Pi,soothing Gan,eliminating dampness and resolving blood stasis diarrhea type irritable bowel syndrome quality of life

基金项目:北京市科委基金资助(No.Z0005190043711);首都发展基金资助(No.SF-2005-9)

作者	单位
吴兵	首都医科大学附属北京中医医院消化中心
张声生	首都医科大学附属北京中医医院消化中心

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中文摘要:

目的观察健脾疏肝、除湿化瘀法对腹泻型肠易激综合征(IBS-D)患者近期生活质量的影响。方法125例IBS-D患者分为3组,观察组采用以健脾疏肝、除湿化瘀立法的方药,随证加减;中成药组采用肠胃康颗粒、固本益肠片、补脾益肠丸、参苓白术丸辨证用药;西药组采用匹维溴胺50mg、谷维素10mg、培菲康420mg,均每天3次口服;3组疗程均为4周;采用国际通用的SF-36生存量表对患者治疗前后的生活质量进行评估。结果治疗后观察组SF-36量表的8个维度〔生理功能(PF)、生理职能(RP)、躯体疼痛(BP)、总体健康(GH)、生命活力(VT)、社会功能(SF)、情感职能(RE)、精神健康(MH)〕积分均得到了显著改善(P<0.05,P<0.01);其中GH、SF及BP、MH优于中成药组(P<0.01,P<0.05);RP、GH、SF、RE及PF、MH优于西药组(P<0.05,P<0.01)。结论健脾疏肝、除湿化瘀法治疗IBS-D有较好的疗效,能够改善患者近期的生活质量。

英文摘要:

Objective To observe the TCM therapy for invigorating Pi,soothing Gan,eliminating dampness and resolving blood stasis(TCM-T)on the short-term quality of life(stQOL)in patients with diarrhea type irritable bowel syndrome(IBS-D).Methods One hundred and twenty-five patients with IBS-D were assigned to 3 groups,Group A was treated with TCM-T;Group B treated with some selected Chinese patent drugs according to patients’ syndrome types,such as Changweikang granule,Guben Yichang tablet,Bupi Yichang pill and Shenling Baizhu pill,Group C treated with Western medicines as Dicetel 50 mg,Oryzanol 10 mg,and Bifid triple viable 420 mg,3 times daily by oral administration.The therapeutic course was 4 weeks for all.The stQOL was evaluated and compared by SF-36 scale before and after treatment.Results Comparison between groups on the scores for the 8 dimensions of SF-36 scale,i.e.,physiological function(PF),role physical(RP),body pain(BP),global health(GH),vitality(VT),society function(SF),emotional effect(RE),and mental health(MH),showed no significant difference before treatment,but scores of all the 8 dimensions were improved significantly in Group A after treatment(P<0.05),with scores of SF,BP,GH and MH superior to those in Group B(P<0.05,P<0.01),and scores of RP,GH,SF,RE,PF and MH superior to those in Group C(P<0.05,P<0.01).Conclusion TCM-T has favorable effect in treating IBS-D,it could improve the stQOL of patients.

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