| 鲁盈,李惊子,郑欣,薛林,洪健美,邹万忠,王海燕.黄芪当归合剂对肾病综合征血清脂谱和肾小球硬化的影响[J].中国中西医结合杂志,1997,(8):478-480 |
| 黄芪当归合剂对肾病综合征血清脂谱和肾小球硬化的影响 |
| Effect of Astragalus Angrlica Mixture on Serum Lipids and Glomerulosclerosis in Rats with Nephrotic Syndrome |
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| DOI： |
| 中文关键词: 黄芪当归合剂 肾病综合征 脂蛋白 局灶性肾小球硬化 |
| 英文关键词:Astragalus Angelica mixture nephrotic syndrome lipoprotein local glomerulosclerosis |
| 基金项目:国家自然科学基金 |
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| 摘要点击次数: 1839 |
| 全文下载次数: 1193 |
| 中文摘要: |
| 为探讨黄芪当归合剂降脂的肾脏保护作用。方法：采用嘌呤霉素引起的肾病综合征大鼠模型，以有效的降脂药普伐他汀作阳性对照，观察黄芪当归合剂的作用。结果：黄芪当归合剂不仅有普伐他汀的降低胆固醇和甘油三酯的作用，还能降低低密度脂蛋白和载脂蛋白Ｂ（１００）（Ｐ＜０．０５）。肾病理和免疫组织化学证实本品在降脂同时还减少了肾小球硬化指数（Ｐ＜０．０１）和细胞外基质的聚积（Ｐ＜０．０１）。结论：黄芪当归合剂具有调节脂质代谢，减轻肾损伤，保护肾功能的作用。 |
| 英文摘要: |
| To confirm the renal protective action of Astragalus Angelica mixture (AAM). Methods: Effect of AAM was observed in puromycin amino-nucleoside induced nephrotic syndrome model of rat, and pravachol, an effective lipid lowering medicine, was used as Positive control. Results: AAM could not only reduce the serum levels of total cholesterol and triglyceride as pravachol did, but also could lower levels of low density lipoprotein and apolipoprotein B100(P＜0. 05). Light microscopic and immuno-histochemical examination revealed that in the same time of lowering serum lipids, this mixture could also cause reduction of glomerular sclerosing index(P＜0.01) and less accumulation of extracellular matrix (P＜0.01 ). Conclusions: AAM has the effects of regulating lipid metabolism, attenuating renal damage and maintaining renal function in rats with nephrotic syndrome. |
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