Effect of subventricular zone irradiation on prognosis of patients with glioblastoma
Sun Qiangqiang1,2, Zong Dan1, Qian Pudong1, Guo Zhen3, He Xia1,2
1The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing 210009, China; 2The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing 210000, China; 3Department of Radiology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing 210009, China
Abstract：Objective To investigate the role of subventricular zone (SVZ) irradiation in the prognosis of patients with glioblastoma (GBM), and to analyze the factors affecting the prognosis of patients with GBM. Methods Clinical data of 52 patients with GBM treated in the Affiliated Cancer Hospital of Nanjing Medical University from 2017 to 2020 were analyzed retrospectively. According to the median dose of ipsilateral or contralateral SVZ, the patients were divided into the high-dose group and low-dose group. The prognostic differences between two groups were compared and the prognostic factors were analyzed. Results The median progression-free survival (PFS) was 17.1 months (95%CI:12.4-30.7)and the median overall survival (OS) was 38.3 months (95%CI:20.4-44.5). Univariate analysis showed that whether the tumor invading SVZ (P = 0.039), the degree of resection (P = 0.009) and MGMT promoter methylation status (P = 0.039) were the influencing factors of PFS. Age (P = 0.018), Kanofsky performance score (P = 0.043), whether the tumor invading SVZ (P = 0.038), degree of resection (P = 0.020) and MGMT promoter methylation status (P = 0.019) were the influencing factors of OS. The analysis of SVZ dose as a continuous variable showed that SVZ dose was the influencing factor of PFS (P < 0.05) rather than OS (P ≥ 0.05). Whether the tumor invading SVZ or not, there was no significant difference in survival between the high-dose and low-dose groups. Multivariate analysis showed that whether the tumor invading SVZ and MGMT promoter methylation were the independent prognostic factor for PFS (both P < 0.05), and OS (both P < 0.05). The SVZ dose related variables were not statistically significant in multivariate analysis. Conclusions Patients with tumors directly invading SVZ achieve worse survival. Increasing the ipsilateral or contralateral SVZ dose does not improve patient survival. Whether SVZ irradiation affects the survival of patients still needs to be further confirmed by prospective randomized clinical studies.
Sun Qiangqiang,Zong Dan,Qian Pudong et al. Effect of subventricular zone irradiation on prognosis of patients with glioblastoma[J]. Chinese Journal of Radiation Oncology, 2022, 31(11): 992-997.
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