| 苗延巍,刘婷,伍建林,宋清伟,张清,张竞文,杨志宏,倪鸣飞.磁敏感加权成像评价正常人大脑灰质核团铁含量[J].中国医学影像技术,2009,25(3):377~379 |
| 磁敏感加权成像评价正常人大脑灰质核团铁含量 |
| Susceptibility weighted imaging evaluation of brain iron content of gray nucleus in healthy people |
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| DOI： |
| 中文关键词: 脑 铁 磁共振成像 |
| 英文关键词:Brain Iron Magnetic resonance imaging |
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| 摘要点击次数: 2054 |
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| 中文摘要: |
| 目的 应用磁敏感加权成像(SWI)技术相对定量分析不同年龄段的正常人脑深部灰质核团(包括黑质、红核、苍白球、壳核、尾状核)的脑铁含量的变化规律。方法 将171名健康志愿者按年龄分为5组:20~29岁、30~39岁、40~49岁、50~59岁、60~69岁,行头部SWI扫描并测量黑质、红核、苍白球、壳、尾状核头部的SWI信号值,分析各部位SWI信号值随年龄的变化规律。结果 不同年龄阶段所测量得到的尾状核头、壳核、苍白球、黑质、红核SWI信号值之间差异有统计学意义(P＜0.001),并按一定规律变化。尾状核、苍白球SWI信号值于20~39岁变化基本平稳,于40岁后随年龄的增长诸深部灰质核团SWI信号值快速下降(以红核及壳核为著)。黑质、红核、壳核、尾状核头SWI信号值均与年龄呈明显负相关(r黑质=－0.759,r红核=－0.875,r壳核=－0.880,r尾状核头=－0.524,P＜0.001);苍白球SWI信号值与年龄存在弱相关(r=－0.211,P=0.042)。结论 SWI信号值可以反映脑铁分布区域性和随年龄变化的规律。 |
| 英文摘要: |
| Objective To observe the changes of brain iron in deep gray nucleus (including substantia nigra, red nucleus, globus pallidus, putamen, caudate nucleus) with susceptibility weighted imaging (SWI) in healthy people. Methods A total of 171 healthy adults (86 males and 85 females) were selected to perform SWI examination. All of volunteers were divided into five age groups in term of ten years: 20-29 (n=31), 30-39 (n=33), 40-49 (n=35), 50-59 (n=40) and 60-69 (n=32). The signal values of substantia nigra, red nucleus, globus pallidus, putamen, caudate nucleus on SWI were quantificationally measured. The relationship between SWI signal values of deep brain gray nucleus and age was analyzed. Results In the 20-39 years old group, SWI signal values of substantia nigra, globus pallidus, red nucleus, caudate nucleus, putamen had statistical differences (P<0.001). The SWI signal values changed in the smooth in caudate nucleus and globus pallidus during the period of 20-39 years old, and increased rapidly after 40 years old in all brain gray nucleus (especially red nucleus and putamen). Obvious correlations between age and SWI signal values were shown in substantia nigra (r=－0.759), red nucleus (r=－0.875), putamen (r=－0.880) and caudate nucleus (r=－0.524), while weakly correlation was displayed in globus pallidus (r=－0.211). Conclusion SWI provides a new method to detect brain iron and quantificationally measure the anatomical localization and age-related iron concentration changes. |
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