Analysis of related factors in clinical staging of nasopharyngeal carcinoma patients
WU Ganggang1, BIAN Xuefei1, ZHOU Qi1, ZHANG Xiaote1, ZHU Yun1, TAO Zeru1, SHAO Shengyan2, FENG Shanshan3, WANG Hongli1, YANG Youxiong1
1.Department of Otolaryngology Head and Neck Surgery, the Second Hospital of Yinzhou District, Ningbo 315100, China; 2.Department of Otolaryngology Head and Neck Surgery, Jiangshan Branch of Yinzhou Second Hospital, Ningbo 315100, China; 3.Physical Examination Center, Ningbo Mingzhou Hospital, Ningbo 315100, China
WU Ganggang,BIAN Xuefei,ZHOU Qi, et al. Analysis of related factors in clinical staging of nasopharyngeal carcinoma patients[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(7): 577-581.
Abstract：Objective: To study the correlation between clinical stage and related factors of nasopharyngeal carcinoma patients, and to provide clinical data for early diagnosis and treatment of nasopharyngeal carcinoma. Methods: From June 2016 to September 2021, 63 patients with nasopharyngeal carcinoma hospitalized for initial diagnosis in the Second Hospital of Yinzhou District, Ningbo (Patients with nasopharyngeal carcinoma were excluded from radiotherapy and chemotherapy) were retrospectively analyzed, and their clinical stages, symptoms of first diagnosis, time of first diagnosis, concomitant symptoms, lymphatic metastasis, tumor growth pattern, pathological type and other characteristics were analyzed. Results: Of 63 patients with nasopharyngeal carcinoma, there were 49 males and 14 females (male: female=3.5:1), aged from 22 to 82 years, with an average of (53.8±1.7) years. There were 17 cases (27.0%) in stage I, 14 cases (22.2%) in stage II, 29 cases (46.0%) in stage III and 3 cases (4.8%) in stage IV, respectively. There were 31 cases in early stage and 32 cases in middle and late stage, with the early diagnosis rate being 49.2%. Symptoms at first diagnosis in the order of occurrence rate were upper neck lymph node enlargement in 24 cases (38.1%), bloodsucking nose in 18 cases (28.5%), nasal obstruction in 10 cases (15.9%), tinnitus in 8 cases (12.7%), nosebleed, headache and no symptoms in 1 case (1.6%) respectively. The time of first diagnosis was (2.4±0.3) months for early-stage patients and (5.4±1.1) months for middle and late stage patients. The proportion of patients with concomitant symptoms was 15/31 (48.4%) and 24/32 (75%), respectively. Logistic regression analysis showed that initial symptoms (lymphadenopathy, nasal blood aspiration), longer initial diagnosis time, concomitant symptoms, and lymph node metastasis were independent risk factors for middle and late clinical stages of nasopharyngeal carcinoma (P<0.05). Conclusion: The clinical stage of nasopharyngeal carcinoma was correlated with first diagnosis symptoms, time of first diagnosis, concomitant symptoms and lymph node metastasis. Shortening the time of first diagnosis is an important means to find early nasopharyngeal carcinoma. Nasopharyngeal examination must be done once within 2 months in cases of reflux, nasal obstruction, tinnitus and stuffy ears, nasal bleeding or lymph node enlargement in upper neck.
