目的 对南海红树林内生真菌黄灰青霉菌Penicillium aurantiogriseum 299的次级代谢产物进行研究。方法 采用色谱技术对Penicillium aurantiogriseum 299 的次级代谢产物进行分离纯化，根据化合物的理化性质、波谱分析数据以及与文献谱图对照的方法确定化合物的结构。结果 从南海红树林内生真菌Penicillium aurantiogriseum 299的次级代谢产物中分离得到了4个化合物，分别鉴定为aurantiogrisidinol a/b（1a/1b）、4-（2'-羟基-丁炔氧基）苯甲酸（2）、（S）-penipratynolene（3）、aurantiamine（4）。结论 化合物1a/1b为新化合物，化合物2是首次从青霉菌属真菌中分离得到。

Objective To study the secondary metabolites of Penicillium aurantiogriseum 299 from South China Sea. Methods The metabolites of P. aurantiogriseum 299 were isolated by chromatographic techniques; The structures of compounds were eventually identified and confirmed on the basis of physicochemical properties, spectral data, and spectra of literatures published. Results Four compounds were isolated from the mangrove endophytic fungus P. aurantiogriseum 299, and their structures were identified as aurantiogrisidinol a/b (1a/1b), 4-(2'-hydroxybutynoxy) benzoic acid (2), (S)-penipratynolene (3), and aurantiamine (4). Conclusion Compound 1 is a new compound. Compound 2 is isolated from P. aurantiogriseum for the first time.

国家自然科学基金资助项目（2127876）；中国博士后科学基金资助项目（2013M531886）；海洋公益性行业科研专项经费项目（210305017）；海洋生物天然产物化合物库基金资助项目（4109041）