Objective: To optimize optimum extraction technology of Danxia Rupi tablet. Method: Tanshinone ⅡA was used as index for alcohol extraction part,extraction time was selected for single factor test.Residue after ethanol extracting and other herbs were extracted by water together,L₉(3⁴) orthogonal experiment was used to determine extraction technology of Danxia Rupi tablet with danshensu as index,extraction time,the amount of solvent and extraction times were investigated as main factors affecting water boiling. Result: Optimum extraction process was:for alcohol extraction part,extracted 1 time with 10 times the amount of 95 % ethanol for 2 h.Water extraction part extracted 3 times with 10 times the amount of water for 2 hours each time. Conclution: This optimum technology was simple, feasible and adapt to industrial production, which could provide references for further investigation of Danxia Rupi tablet.