[1]赵士娇 韩雪 高燕军.急性脑梗死患者血浆骨桥蛋白水平与颈动脉内膜中层厚度的相关性研究[J].卒中与神经疾病杂志,2019,26(01):36-38.[doi:10.3969/j.issn.1007-0478.2019.01.008]
　Zhao Shijiao,Han Xue,Gao Yanjun..The relationship between plasma osteopontin and carotid intimal medial thickness in acute cerebral infarction[J].Stroke and Nervous Diseases,2019,26(01):36-38.[doi:10.3969/j.issn.1007-0478.2019.01.008]
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急性脑梗死患者血浆骨桥蛋白水平与颈动脉内膜中层厚度的相关性研究()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第26卷
期数:
2019年01期
页码:
36-38
栏目:
论 著
出版日期:
2019-02-26

文章信息/Info

Title:
The relationship between plasma osteopontin and carotid intimal medial thickness in acute cerebral infarction
文章编号:
1007-0478(2019)01-0036-03
作者:
赵士娇 韩雪 高燕军
067000 河北省承德医学院(赵士娇 韩雪); 承德医学院附属医院[高燕军(通信作者)]
Author(s):
Zhao Shijiao;  Han Xue;  Gao Yanjun.
Department of Neurology, Affiliated Hospital of Chengde Medical College, Chengde Hebei 067000
关键词:
急性脑梗死 骨桥蛋白 颈动脉内膜中层厚度 动脉粥样硬化
Keywords:
Acute cerebral infarction Osteopontin Carotid intimal medial thickness Atherosclerosis
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2019.01.008
文献标志码:
A
摘要:
目的 探讨急性脑梗死患者血浆骨桥蛋白(OPN)水平与颈动脉内膜中层厚度(IMT)的关系。方法 选择符合急性脑梗死诊断标准的患者150例,选择同期来院体检的健康志愿者65例为对照组; 将脑梗死组按颈动脉IMT值分为ACI无颈动脉斑块组74例和ACI合并颈动脉斑块组76例; 检测所有研究对象的血浆OPN水平,通过颈动脉多普勒超声测量颈总动脉IMT值。结果 ACI无颈动脉斑块组血浆OPN水平较对照组升高(P<0.05); ACI合并颈动脉斑块组血浆OPN水平较对照组升高更显著。ACI患者血浆OPN水平与颈动脉内膜中层厚度(rs=0.291,P<0.05)呈正相关。结论 急性脑梗死患者血浆OPN水平升高,且与颈动脉内膜中层厚度呈正相关,提示OPN可能参与急性脑梗死患者动脉粥样硬化的发生、发展。
Abstract:
ObjectiveTo investigate the relationship between plasma osteopontin level and carotid intimal medial thickness in patients with ACI.Methods 150 cases of acute cerebral infarction were Selected as cerebral infarction group.65 healthy subjects were collected as controls depending on routine health examination.Carotid intima media thickness(IMT)was measured with color Doppler ultrasound.The patients were divided into ACI group without carotid artery atherosclerosis(74 cases)and ACI group with carotid artery atherosclerosis(76 cases),depending on IMT.Plasma osteopontin levels were determined in 150 ACI patients and 65 healthy controls respectively.Results Plasma osteopontin levels were increased in 74 essential ACI patients with IMT<1.0 mm as compared with 65 healthy controls.Plasma osteopontin levels were increased more significantly in 76 ACI patients with IMT≥1.0 mm as compared with 65 healthy controls.A positive relationship was found between IMT and plasma osteoponin level in ACI patients(rs=0.291,P<0.05).Conclusion Plasma osteoponin level increased in ACI patients,especially in the patients with carotid atherosclerosis.Plasma osteoponin level was positively correlated with carotid IMT, which suggested the role of osteoponin in process of atheroscterosis.

参考文献/References:


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备注/Memo

备注/Memo:
作者单位:067000 河北省承德医学院(赵士娇 韩雪); 承德医学院附属医院[高燕军(通信作者)]
更新日期/Last Update: 2019-02-20