Allergic rhinitis (AR) is a noninfectious inflammatory disease of the nasal mucosa mediated by IgE. The imbalance of Th1/Th2/ Th17/Treg cells is an important immunological feature of AR. The silent information regulator 2 homolog 1(SIRT1) as a Class III family of histone deacetylase enzymes, plays a significant role in DNA repair and apoptosis, muscle and adipose differentiation, neuron proliferation and differentiation, metabolism, inflammatory response and oxidative stress. The recent researches on SIRT1 in allergic diseases mainly focus on rheumatoid arthritis, systemic lupus erythematosus and asthma. There are few studies on SIRT1 in AR. This article summarized the relevant researches on the role of SIRT1 in AR.