Objective: To observe effect of Baoji Wan powder on diarrhea and intestinal motility induced by irradiation in mice. Method: Using castor oil induced diarrhea model, we observed Baoji Wan powder’s(before and after irradiation) antidiarrheal effect at doses of 1.3,2.6,5.2 g·kg^-1ig for 3 d in mice. Using pyridostigmine bromide induced hyperthyroidism intestine movement in mice, the effect of Baoji Wan powder on intestine movements was observed. Result: Baoji Wan powder before and after irradiation could significantly extend the castor oil-induced small diarrhea, the starting time of diarrbea(indicated by watery feces), the number of diarrhea, compared with the control group (P<0.01). The powder could significantly inhibit pyridostigmine bromide-induced intestinal motility compared with that in the model group (P<0.01, P<0.05); and it could significantly reduce the water content in colon and small intestine, compared with that in normal control group (P<0.01, P<0.05). Conclusion: Baoji Wan powder before and after irradiation has the effect of inhibiton of diarrhea and suppression of bowel movement, the antidiarrheal effect may be gained by inhibition of bowel movements and reduce of water in intestine.Before and after irradiation, Baoji Wan powder’s difference in effects was not significant.