| Periprosthetic joint infection is a serious complication after arthroplasty, which may cause serious health and economic burden. At present, the diagnosis of PJI is difficult due to the interference of multiple confounding factors. Traditional serological examination and imaging examination have certain value, but they are easy to be affected by systemic conditions, resulting in low specificity. In order to correctly diagnose the PJI, many methods involving different disciplines have been tried. In recent years, the detection of inflammatory markers of synovial fluid,and molecular biological methods have been proved to have high sensitivity and specificity. Therefore, joint synovial fluid CRP, α-defensin, leukocyte esterase, PCR technology and other technologies have been widely studied, hoping to find reliable indicators for the diagnosis of joint prosthesis infection and guide clinical application. |
