|本期目录/Table of Contents|

环状RNA在肿瘤中的研究进展

《现代肿瘤医学》[ISSN:1672-4992/CN:61-1415/R]

期数:
2019年19期
页码:
3516-3520
栏目:
综述
出版日期:
2019-08-29

文章信息/Info

Title:
Progression of circular RNA in tumors
作者:
江丽华; 王朝霞
南京医科大学第二附属医院肿瘤科，江苏 南京 210011
Author(s):
Jiang Lihua; Wang Zhaoxia
Department of Oncology，the Second Affiliated Hospital of Nanjing Medical University，Jiangsu Nanjing 210011，China.
关键词:
环状RNA; 肿瘤; 生物标志物
Keywords:
circular RNA; tumor; bio-marker
分类号:
R730.4
DOI:
10.3969/j.issn.1672-4992.2019.19.037
文献标识码:
A
摘要:
环状RNA（circular RNA，circRNA）是一种共价闭合环状结构的非编码RNA，广泛存在于生物体中，具有结构稳定、高度保守性及特异性表达的特性。研究表明，circRNA可作为竞争性内源RNA（competing endogenous RNAs，ceRNA），调控基因表达或结合RNA相关蛋白发挥生物学功能。circRNA在肿瘤的发生发展中扮演了重要角色，有望成为肿瘤诊断的生物标志物及治疗靶点。本文结合国内外的最新研究，对circRNA在肿瘤中的研究进展作一综述。
Abstract:
Circular RNA（circRNA） as a covalently closed circular non-coding RNA，exists in a variety of biological cells，characterized by the stable structure，conserved sequence and tissue-specificity.Studies show that circRNAs function is as ceRNAs.circRNAs are involved in the regulation of gene expression and binding with RNA-binding proteins.circRNAs play an important role in tumor development and progression and serve as potential bio-markers.In this review，we summarize the latest progress，both in domestic and foreign studies，on the progression of circRNAs in tumors.

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备注/Memo

备注/Memo:
National Natural Science Foundation of China(No.81871871）；国家自然科学基金（编号：81871871）；江苏省医学创新团队基金（编号：CXTDA2017021）
更新日期/Last Update: 2019-08-29