定坤丹治疗子宫内膜薄型不孕的临床效果

doi:10.3969/j.issn.1006-7795.2022.03.006

首都医科大学学报 ›› 2022, Vol. 43 ›› Issue (3): 364-368.doi: 10.3969/j.issn.1006-7795.2022.03.006

• 更年期妇科内分泌与生育力保护 • 上一篇下一篇

定坤丹治疗子宫内膜薄型不孕的临床效果

金凤羽¹, 阮祥燕^1*, 秦爽¹, 许新¹, 杨瑜¹, 谷牧青¹, 李妍秋¹, 杜娟¹, 程姣姣¹, 尹晓丹²

1.首都医科大学附属北京妇产医院/北京妇幼保健院内分泌科,北京 100026;
2.首都医科大学附属北京妇产医院/北京妇幼保健院中医科,北京 100026

收稿日期:2022-02-27 出版日期:2022-06-21 发布日期:2022-06-01
基金资助:
北京市属医院科研培育项目(PZ2019031),北京市医院管理局“登峰”计划专项(DFL20181401)。

Clinical effects of Dingkun pill on thin endometrium infertility

Jin Fengyu ¹, Ruan Xiangyan^1*, Qin Shuang¹, Xu Xin¹, Yang Yu¹, Gu Muqing¹, Li Yanqiu¹, Du Juan¹, Cheng Jiaojiao¹, Yin Xiaodan²

1. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing 100026, China;
2. Department ofTraditional Chinese Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing 100026, China

Received:2022-02-27 Online:2022-06-21 Published:2022-06-01
Contact: *E-mail:ruanxiangyan@ccmu.edu.cn
Supported by:
Beijing Municipal Administration of Hospitals Incubating Program(PZ2019031), Beijing Municipal Administration of Hospitals' Ascent Plan (DFL20181401).

摘要/Abstract

摘要： 目的观察定坤丹治疗子宫内膜薄型不孕的临床效果,为优化子宫内膜薄型不孕的治疗方案提供参考。方法选取187例子宫内膜薄型不孕患者,在保证组间基本特征匹配原则上,利用计算机软件产生的随机数,按照1∶1的比例分为对照组(93例)和观察组(94例)。对照组给予雌二醇+地屈孕酮干预,观察组在对照组的基础上加用定坤丹。比较治疗3个周期后两组患者的子宫内膜厚度、孕激素浓度及临床妊娠率。结果观察组患者排卵期平均子宫内膜厚度显著高于对照组(P<0.01),黄体期孕激素浓度显著高于对照组(P<0.01),累计临床妊娠率显著高于对照组(P<0.05)。结论定坤丹可以明显改善子宫内膜薄型不孕患者排卵期子宫内膜厚度,提高黄体功能,改善妊娠结局。

关键词: 子宫内膜薄型, 不孕, 定坤丹, 妊娠

Abstract: Objective To optimize the treatment methods of thin endometrial infertility and provide more effective clinical options. Methods A total of 197 patients with thin endometrium infertility were randomly assigned to the control group and the experimental group. The endometrial thickness, progesterone level and clinical pregnancy rate between the two groups were compared to each other. The control group was treated with estradiol + dydrogesterone, while the experimental group was treated with Dingkun pill in addition to the treatment in the control group. Results Compared to that in the control group, the average endometrial thickness during ovulation (P<0.01),the progesterone level in luteal phase (P<0.01) ,and the cumulative clinical pregnancy rate was significantly higher (P<0.05) in the experimental group. Conclusion Dingkun pill could significantly improve the endometrial thickness, luteal function and pregnancy outcome in thin endometrial infertility.

Key words: thin endometrium, infertility, Dingkun pill, pregnance

中图分类号:

R711.6

金凤羽, 阮祥燕, 秦爽, 许新, 杨瑜, 谷牧青, 李妍秋, 杜娟, 程姣姣, 尹晓丹. 定坤丹治疗子宫内膜薄型不孕的临床效果[J]. 首都医科大学学报, 2022, 43(3): 364-368.

Jin Fengyu , Ruan Xiangyan, Qin Shuang, Xu Xin, Yang Yu, Gu Muqing, Li Yanqiu, Du Juan, Cheng Jiaojiao, Yin Xiaodan. Clinical effects of Dingkun pill on thin endometrium infertility[J]. Journal of Capital Medical University, 2022, 43(3): 364-368.

参考文献

[1] 马黔红. 辅助生殖技术的新进展[J]. 中国计划生育和妇产科, 2017, 9(1): 4-7.
[2] Wadhwa L, Fauzdar A, Wadhwa S N. An intrauterine insemination audit at tertiary care hospital: 4^1/2 years' retrospective analysis of 800 intrauterine insemination cycles[J]. J Hum Reprod Sci, 2018, 11(3): 279-285.
[3] Vaegter K K, Lakic T G, Olovsson M, et al. Which factors are most predictive for live birth after in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI) treatments? Analysis of 100 prospectively recorded variables in 8,400 IVF/ICSI single-embryo transfers[J]. Fertil Steril, 2017, 107(3): 641-648.e2.
[4] Kasius A, Smit J G, Torrance H L, et al. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis[J]. Hum Reprod Update, 2014, 20(4): 530-541.
[5] Liu K E, Hartman M, Hartman A, et al. The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: an analysis of over 40000 embryo transfers[J]. Hum Reprod, 2018, 33(10): 1883-1888.
[6] Kunicki M, Lukaszuk K, Woclawek-Potocka I, et al. Evaluation of granulocyte colony-stimulating factor effects on treatment-resistant thin endometrium in women undergoing in vitro fertilization[J]. Biomed Res Int, 2014, 2014: 913235.
[7] Zolghadri J, Haghbin H, Dadras N, et al. Vagifem is superior to vaginal Premarin in induction of endometrial thickness in the frozen-thawed cycle patients with refractory endometria: a randomized clinical trial[J]. Iran J Reprod Med, 2014, 12(6): 415-420.
[8] Shen M S, Wang C W, Chen C H, et al. New horizon on successful management for a woman with repeated implantation failure due to unresponsive thin endometrium: use of extended estrogen supplementation[J]. J Obstet Gynaecol Res, 2013, 39(5): 1092-1094.
[9] Cai H H, Li H J, He Y L. Interceed and estrogen reduce uterine adhesions and fibrosis and improve endometrial receptivity in a rabbit model of intrauterine adhesions[J]. Reprod Sci, 2016, 23(9): 1208-1216.
[10] Amir W, Micha B, Ariel H, et al. Predicting factors for endometrial thickness during treatment with assisted reproductive technology[J]. Fertil Steril, 2007, 87(4): 799-804.
[11] Malhotra N, Bahadur A, Kalaivani M, et al. Changes in endometrial receptivity in women with Asherman's syndrome undergoing hysteroscopic adhesiolysis[J]. Arch Gynecol Obstet, 2012, 286(2): 525-530.
[12] 施勇, 彭丹红, 高永星, 等. 补佳乐联合芬吗通及阿司匹林预防中-重度宫腔粘连HEOS冷刀术后复发的效果评价[J]. 东南大学学报:医学版, 2019, 38(5): 873-876.
[13] Almeida-Francia C C D, Keator C S, Mah K, et al. Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque[J]. Hum Reprod, 2012, 27(6): 1723-1734.
[14] 周丹, 唐兴荣, 林汉瑜, 等. 中医治疗肾虚型排卵障碍性不孕症的Meta分析[J]. 湖南中医药大学学报, 2017, 37(9): 961-965.
[15] 郑娟, 谈勇. 定坤丹联合戊酸雌二醇对肾阳虚薄型子宫内膜大鼠Wnt/β-catenin信号通路的影响[J]. 四川大学学报:医学版, 2021, 52(2): 235-240.
[16] 王海文, 阮祥燕, Wallwiener D, 等. 资癸女贞胶囊对子宫内膜薄性不育症妊娠结局影响的研究[J]. 首都医科大学学报, 2014, 35(4): 419-423.
[17] 周冬梅, 滑玮, 黄艳红. 定坤丹对复苏周期子宫内膜及妊娠结局的影响[J]. 中国妇幼健康研究, 2018, 29(4): 511-513.
[18] 李嘉慧, 欧妍. 定坤丹结合激素治疗肾虚肝郁证月经过少患者的临床疗效及对子宫内膜厚度的影响[J]. 世界中医药, 2018, 13(3): 669-671, 675.

定坤丹治疗子宫内膜薄型不孕的临床效果

Clinical effects of Dingkun pill on thin endometrium infertility

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