| 引用本文:柳晴1,2，庄开颜1,3,4，张云1,3,4，何秋霞1,3,4，刘可春1,3,4，夏青1,3,4，周洪雷2.心可舒化学成分与药理作用研究进展[J].世界中医药,2022,(20):. |
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| 心可舒化学成分与药理作用研究进展 |
| Chemical Constituents and Pharmacological Mechanism of Xinkeshu |
| 投稿时间：2020-12-25 |
| DOI：10.3969/j.issn.1673-7202.2022.20.025 |
| 中文关键词: 心可舒 化学成分 心肌缺血 心肌缺血再灌注损伤 内皮保护 心肌代谢紊乱 钙离子通路 综述 |
| English Keywords:Xinkeshu Chemical constituents Myocardial ischemia Myocardial ischemia-reperfusion injury Endothelial protection Myocardial metabolic disorders Calcium pathway Review |
| 基金项目:国家重点研发计划项目（2018YFC1707300）；山东省自然科学基金青年项目（ZR2021QH155）；山东省重点研发计划（重大科技创新工程）项目（2021CXGC010511） |
| 作者 | 单位 | | 柳晴1,2，庄开颜1,3,4，张云1,3,4，何秋霞1,3,4，刘可春1,3,4，夏青1,3,4，周洪雷2 | 1 齐鲁工业大学，山东省科学院生物研究所，济南，250103； 2 山东中医药大学药学院，济南，250355； 3 山东省人类疾病斑马鱼模型与药物筛选工程技术研究中心，济南，250103； 4 济南市中药质量生物评价工程研究中心，济南，250103 |
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| 中文摘要: |
| 心可舒是临床治疗冠心病的中成药大品种，由丹参、葛根、山楂、三七、木香5味药食同源中药制成，具有活血化瘀、行气止痛之功效，临床用于治疗不稳定型心绞痛等冠心病病症，疗效确切。心可舒化学成分主要为丹参酚酸类，葛根黄酮类，三七皂苷类，山楂黄酮类、三萜类和木香倍半萜类成分等。药理作用主要涉及抗心肌缺血、抗缺血再灌注损伤、改善内皮功能、抗焦虑/抑郁、抗炎、抗血小板聚集等。现查阅国内外文献，对心可舒化学成分、药理作用及机制进行归纳分析，以期为其进一步研究、质量控制提升和二次开发等提供参考。 |
| English Summary: |
| Xinkeshu,a major variety of Chinese patent medicine for the treatment of coronary heart disease in the clinic,is composed of Salviae Miltiorrhizae Radix et Rhizoma,Puerariae Lobatae Radix,Notoginseng Radix et Rhizoma,Crataegi Fructus,and Aucklandiae Radix.It has the functions of activating blood circulation,removing blood stasis,promoting qi,and relieving pain.It is clinically used in the treatment of coronary heart disease such as unstable angina pectoris,with accurate curative effect.The chemical constituents of Xinkeshu are salvianolic phenolic acids of Salvia miltiorrhiza,flavonoids of Pueraria lobata,saponins of Panax notoginseng,flavonoids and triterpenoids of Crataegus pinnatifida Bunge,and sesquiterpenoids of Aucklandia lappa.The pharmacological effects mainly involve anti-myocardial ischemia,anti-ischemia-reperfusion injury,improvement of endothelial function,anti-anxiety/depression,anti-inflammation,anti-platelet aggregation,etc.In this paper,the Chinese and foreign studies were retrieved to summarize and analyze the chemical constituents,pharmacological effects,and mechanisms of Xinkeshu,to provide references for its quality control improvement,secondary development,and clinical rational use. |
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